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Saturday, April 18, 2020 | History

2 edition of Estrogen-induced tumors of the kidney in the Syrian hamster. found in the catalog.

Estrogen-induced tumors of the kidney in the Syrian hamster.

Hadley Kirkman

Estrogen-induced tumors of the kidney in the Syrian hamster.

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  • 9 Currently reading

Published by U.S.Dept.of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Cancer Institute in [Bethesda, Md.] .
Written in English

    Subjects:
  • Kidneys -- Tumors,
  • Hamsters

  • Edition Notes

    Includes bibliographies.

    SeriesNational Cancer Institute monograph,, no. 1
    Classifications
    LC ClassificationsRC261 .A448 no. 1
    The Physical Object
    Paginationiii, 139p.
    Number of Pages139
    ID Numbers
    Open LibraryOL5814708M
    LC Control Number60061370
    OCLC/WorldCa1876666

    The International Life Sciences Institute (ILSI) was estab lished to stimulate and support scientific research and edu cational programs in nutrition, toxicology, and food safe ty; and to encourage cooperation in these programs among scientists from universities, industry, and government in order to facilitate the resolution of health and safety issues. Note: Citations are based on reference standards. However, formatting rules can vary widely between applications and fields of interest or study. The specific requirements or preferences of your reviewing publisher, classroom teacher, institution or organization should be applied.


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Estrogen-induced tumors of the kidney in the Syrian hamster. by Hadley Kirkman Download PDF EPUB FB2

Diethylstilbestrol (DES)-induced kidney tumor of the Syrian golden hamster estrogen(E2)-dependent renal tumor E2-induced nephroblastoma E 2 -induced clear cell carcinoma hormonal-dependent carcinoma. This is a preview of subscription content, log in to check software-comparativo.com by: 4.

Estrogen-induced tumors of the kidney in the Syrian hamster. [Bethesda, Md.] U.S. Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Cancer Institute, (OCoLC) Online version: Kirkman, Hadley, Estrogen-induced tumors of the kidney in the Syrian hamster.

Get this from a library. Estrogen-induced tumors of the kidney in the Syrian hamster. [Hadley Kirkman]. Following long-term estrogen treatment the Syrian hamster develops renal adenocarcinomas which are both estrogen-induced and estrogen-dependent (Kirkman, ). We have been using this model to find answers for several questions concerning the induction and growth of hormone-dependent tumors with emphasis on the role of estrogen at the Cited by: 2.

Natl Cancer Inst Monogr. Dec; Estrogen-induced tumors of the kidney. Histology and histogenesis in the Syrian hamster. KIRKMAN H, ROBBINS software-comparativo.com by: The estrogen-induced Syrian hamster tumors of the kidney have emerged as one of the most intensively studied in-vivo models in solely estrogen-induced oncogenesis.

An advantage of this model is that the tumors occur in the absence of any intervening morphologic changes, but rather they are the result of the continuous progression of a subset of Cited by: Cortes V, Peydro-Olaya A, Llombart-Bosch A () Morphological and immunohistochemical support for the interstitial cell origin of estrogen-induced kidney tumors in the Syrian golden hamster.

Carcinogenesis, in software-comparativo.com by: 3. Specific binding of [3 H]-estradiol to isolated cytosol and to nuclei in tissue slices was determined in hamster kidney before and during estrogen-induced renal tumorigenesis and in the kidney of normal rats, a species which does not develop the software-comparativo.com 10 −9 M [3 H]-estradiol, cytosol from normal hamster kidney bound ± × 10 −15 mol/mg protein, which was significantly less than Cited by: 4.

The estrogen-induced kidney tumor in hamsters has been investigated extensively as a mechanistic model for estrogen-associated cancers in humans, such as breast or uterine cancers. In the hamster model, several synthetic steroidal estrogens like 17α-ethinylestradiol, 2-fluoroestradiol, and 11β-methylestradiol have been identified.

It has been suggested that estrogens play a dual role as both tumor initiators inducing DNA Cited by: Delta differential PCR technique on RNA isolated from estrogen-induced hamster renal tumors and untreated control kidneys identified a number of cDNA fragments that were differentially expressed in tumor RNA compared with untreated controls.

We report the cloning of one of the differentially expressed cDNA fragments, Cited by: 9. hamsters was not expected to alter kidney tumor frequencies. The estrogen-induced Syrian hamster kidney tumor (8) was selected for attempts to modulate tumorigenesis by coadminis tration of vitamin C, because estrogen alone induced neoplasms, because of the high tumor incidence, and because of the estro gen dependence of the tumor for growth (8, 26).

Somatic mutations in stilbene estrogen-induced Syrian hamster kidney tumors identified by DNA software-comparativo.com Available via license: CC BY-NC-SA Content may be subject to copyright.

Inhibition of estrogen-induced renal cell carcinogenesis in male Syrian hamsters by Tamoxifen without decrease in DNA adduct levels. and Robbins, M. Estrogen-induced tumors of the kidney. Jun 01,  · Estrogen-induced covalent DNA modifications likewise were not detectable in tumors grown in estrogenized hamsters inoculated with H cells.

In contrast, DNA was hypomethylated in primary tumors induced by E-diethylstilbestrol, estradiol or 11β-ethyl-l7α-ethinyl estradiol, but not in untreated and estrogen-exposed kidney.

Compared with kidney tissue, there was an 11–24% decrease in total genomic DNA methylation in the estrogen-induced Cited by: Cancer Res. Feb; 10 (2)– KIRKMAN H. Estrogen-induced tumors of the kidney. III. Growth characteristics in the Syrian hamster. Natl Cancer Inst Monogr.

Dec; – Pour P, Mohr U, Althoff J, Cardesa A, Kmoch N. Spontaneous tumors and common diseases in two colonies of Cited by: Characterization of Early Kidney Lesions in Estrogen-induced Tumors in the Syrian Hamster. A new approach, employing histochemical and electron-microscopic techniques was used in an attempt to obtain a more complete knowledge of estrogen-induced kidney tumor in the golden hamster (G.H.).

Three estrogen derivatives, diethylstilbestrol (DES), diethylstilbestrol monoglucoronide (DESGA), and dimethyl ether (DESDME), were used on non Cited by: Chronic exposure to estradiol or other estrogens causes kidney cancer in male Syrian hamsters with effectiveness reaching % [1], [12], [13], [15], [16].

Induction of carcinogenesis is thought to be associated with redox cycling starting with 4-hydroxy or 2-hydroxy estradiol software-comparativo.com by: 4. Dec 01,  · Hadley Kirkman, R. Bacon, Estrogen-Induced Tumors of the Kidney. Estrogen-Induced Kidney Tumors in the Golden Hamster.

Biochemical Composition During Tumorigenesis. Inhibition of Estrogen Tumorigenesis in the Syrian Golden Hamster Kidney by software-comparativo.com by: The mechanism of estrogen-induced and -dependent kidney carcinogenesis in Syrian hamsters and the cell of origin of the tumor are not well understood; they have been investigated in this study by.

Insofar as the same lineage markers have been demonstrated in DES-induced Syrian hamster kidney tumors (SHKT), we conclude that HKT cells retain some of the original tumor cell phenotype.

The current observations suggest that estrogen-induced SHKT derive from the renal interstitium and point to an involvement of neuroectodermal cells in Cited by: hamster kidney as the cell of origin of the DES-induced neoplasm. INTRODUCTION Both steroid and stilbene estrogens are known to be potent carcinogenic agents in the Syrian golden hamster (1), and estrogens and their metabolites have been implicated in the induction of malignant renal tumors Cited by: BibTeX @MISC{Singh04somaticmutations, author = {Kamaleshwar P Singh and Deodutta Roy}, title = {Somatic mutations in stilbene estrogen-induced Syrian hamster kidney tumors identified by DNA fingerprinting}, year = {}}.

Characterization of early kidney lesions in estrogen-induced tumors in the Syrian hamster. Cancer Res. Apr 1; 51 (7)– Oberley TD, Lauchner LJ, Pugh TD, Gonzalez A, Goldfarb S, Li SA, Li JJ.

Specific estrogen-induced cell proliferation of cultured Syrian hamster renal proximal tubular cells in serum-free chemically defined media. Somatic mutations in stilbene estrogen-induced Syrian hamster kidney tumors identified by DNA fingerprinting. DOI: / Singh Kamaleshwar P,Roy Deodutta.

Keywords: Diethylstilbestrol, Random Amplified Polymorphic DNA, Mutations, Kidney tumors. Sep 01,  · In vitro characterization of estrogen induced Syrian hamster renal tumors: comparison with an immortalized cell line derived from diethylstilbestrol-treated adult hamster kidney.

Gonzalez A, Oberley TD, Schultz JL, Ostrom J, Li JJ. In Vitro Cell Dev Biol Anim, 29A(7), 01 Jul Cited by: Apr 01,  · Characterization of Early Kidney Lesions in Estrogen-induced Tumors in the Syrian Hamster Terry D. Oberley, Alfonso Gonzalez, L. Jayne Lauchner, Larry W.

Oberley and Jonathan J. Li Cancer Res April 1 (51) (7) ;Cited by: Estrogens are risk factors for human breast cancer and induce kidney tumors in Syrian hamsters. Mechanistic features of the estrogen-induced hamster kidney tumor model have been compared with corresponding aspects of human breast cancer to gain insight into Cited by: It has long been recognized that the renal proximal tubular epithelium of the hamster is a bona fide estrogen target tissue.

The effect of estrogens on the growth of proximal tubule cell explants and dissociated single cells derived from these explant outgrowths has been studied in software-comparativo.com by: Estrogen-induced tumors of the kidney.

Incidence of renal tumors in intact and gonadectomized male golden hamsters treated with diethylstilbestrol. EFFECT OF ENDOCRINE ABLATION PROCEDURES ON THE TRANSPLANTED OESTROGEN-INDUCED RENAL TUMOUR OF THE SYRIAN HAMSTER. BLOOM HJ, BAKER WH, DUKES CE, MITCHLEY BC.

Br J. However, the identification of mutations common to both stilbene estrogen-induced tumors and the uninvolved (non-tumor) surrounding kidney tissues adjacent to tumors strongly suggests that stilbene estrogen treatment may be responsible for some of the early Cited by: Feb 15,  · Abstract.

Chronic natural or synthetic estrogen treatment of Syrian golden hamsters leads to the development of malignant renal neoplasms. In the present study, morphological and immunohistochemical studies were performed to further characterize the estrogen-induced hamster renal software-comparativo.com by: The lipid profiles of estrogen-induced primary renal carcinomas and hormone-dependent and -independent transplanted tumors were compared with those of both normal hamster kidneys and renal tissues of tumor-bearing animals.

Estrogen-induced tumors of the kidney. Histopathology and cell proliferation induced by 2,2,4-trimethylpentane in the male rat kidney. Inhibition of estrogen-induced renal carcinomas in Syrian hamsters by vitamin C. Cancer Res. Trotte et al., Spontaneous renal adenocarcinoma in a Syrian hamster (Mesocricetus auratus): frequency, morphological and immunohistochemical findings.

Braz J Vet Pathol,3(2), Somatic mutations in stilbene estrogen-induced Syrian hamster kidney tumors identified by DNA fingerprinting. RAPD-PCR provides an alternative molecular approach for studying cancer cytogenetics in stilbene estrogen-induced tumors in humans and experimental models.

Although the exact functional importance of mutated loci is unknown, this Author: Singh Kamaleshwar P and Roy Deodutta. Somatic mutations in stilbene estrogen-induced Syrian hamster kidney tumors identified by DNA fingerprinting. By Roy Deodutta and Singh Kamaleshwar.

Abstract Abstract Kidney tumors from stilbene estrogen (diethylstilbestrol)-treated Syrian hamsters were screened for somatic genetic alterations by Random Amplified Polymorphic DNA. In studies of hormonal carcinogenesis the estrogen-induced renal carcinoma of the Syrian hamster provides a particularly useful experimental model.

The tumor was first reported in (57). Subsequently, it has been studied extensively in many laboratories, resulting in Cited by: Aug 01,  · These investigations in intact cells, capable of performing all biochemical processes, complement both in vivo and subcellular biochemical studies and may aid in elucidating the roles of estrogens and estrogen metabolism in the initiation and development of estrogen-induced, estrogen-dependent kidney tumors in the Syrian software-comparativo.com by: Induction of nuclear catechol-O-methyltransferase by estrogens in hamster kidney: Implications for estrogen-induced renal cancer Judith Weisz 1,2, Gabriella Fritz-Wolz 2, Gary software-comparativo.comn3,4, Catharine software-comparativo.comct5, Catherine Abendroth3 and Cyrus software-comparativo.coming6 Departments of 2Obstetrics and Gynecology, 3Pathology, 4Biochemistry and.

Somatic mutations in stilbene estrogen-induced Syrian hamster kidney tumors identified by DNA fingerprinting. DNA relative to control DNA indicate that loci have undergone allelic losses and gains, respectively, in the stilbene estrogen-induced tumor cell genome.

The presence or absence of the amplified DNA fragments indicate homozygous Author: Kamaleshwar P Singh and Deodutta Roy.The estrogen-induced and -dependent Syrian hamster renal tumor is the most intensively studied model in estrogen carcinogenesis.

Yet, it remains confounding that the kidney of this species behaves as an estrogen target software-comparativo.com by: title = "Hypomethylation of DNA in estrogen-induced and -dependent hamster kidney tumors", abstract = "The development and maintenance of DNA hypomethylation were investigated in male Syrian hamsters during the course of induction of renal carcinoma by estrogens and in an estrogen-dependent tumor derived from H software-comparativo.com by: